Glibenclamide in aneurysmatic subarachnoid hemorrhage (GASH): study protocol for a randomized controlled trial
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چکیده
منابع مشابه
Timing of operation for poor-grade aneurysmal subarachnoid hemorrhage: study protocol for a randomized controlled trial
BACKGROUND Subarachnoid hemorrhage is a common and dangerous disease with an unfavorable prognosis. Patients with poor-grade subarachnoid hemorrhage (Hunt & Hess Grades 4-5) are unconscious on admission. Because of the high mortality and disability rate associated with poor-grade subarachnoid hemorrhage, it is often treated conservatively. Timing of surgery for poor-grade aneurysmal subarachnoi...
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BACKGROUND A frequent complication in patients with subarachnoid hemorrhage (SAH) is recurrent bleeding from the aneurysm. The risk is highest within the first 6 hours after the initial hemorrhage. Securing the aneurysm within this timeframe is difficult owing to logistical delays. The rate of recurrent bleeding can also be reduced by ultra-early administration of antifibrinolytics, which proba...
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Background and Purpose—Magnesium reverses cerebral vasospasm and reduces infarct volume after experimental subarachnoid hemorrhage (SAH) in rats. We aimed to assess whether magnesium reduces the frequency of delayed cerebral ischemia (DCI) in patients with aneurysmal SAH. Methods—Patients were randomized within 4 days after SAH. Magnesium sulfate therapy consisted of a continuous intravenous do...
متن کاملMagnesium sulfate in aneurysmal subarachnoid hemorrhage: a randomized controlled trial.
BACKGROUND AND PURPOSE Magnesium reverses cerebral vasospasm and reduces infarct volume after experimental subarachnoid hemorrhage (SAH) in rats. We aimed to assess whether magnesium reduces the frequency of delayed cerebral ischemia (DCI) in patients with aneurysmal SAH. METHODS Patients were randomized within 4 days after SAH. Magnesium sulfate therapy consisted of a continuous intravenous ...
متن کاملRandomized Controlled Trial of Acetylsalicylic Acid in Aneurysmal Subarachnoid Hemorrhage
Background and Purpose—A previous systematic review of randomized trials suggested a positive effect of antiplatelet therapy in patients with aneurysmal subarachnoid hemorrhage (SAH). We performed a randomized controlled trial to assess whether acetylsalicylic acid (ASA) reduces the risk of delayed ischemic neurological deficit (DIND) in patients with SAH. Methods—Criteria for inclusion were an...
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ژورنال
عنوان ژورنال: Trials
سال: 2019
ISSN: 1745-6215
DOI: 10.1186/s13063-019-3517-y